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  • Tabrecta and Tepmetko are approved simultaneously for NSCLC
  • by | translator Alice Kang | Nov 25, 2021 05:56am
Two MET inhibitors for NSCLC, Tabrecta and Tepmetko, are approved in Korea
Both simultaneously approved for the treatment of non-small cell lung cancer in patients with MET exon 14 skipping mutation
Novartis vs. Merck¡¦ studies on combination with EGFR inhibitor also active
Two new anticancer drugs that target the MET gene to treat non-small cell lung cancer have entered the Korean market. The two drugs are Novartis¡¯ ¡®Tabrecta (capmatinib)¡¯ and Merck¡¯s ¡®Tepmetko (tepotinib)¡¯

The Ministry of Food and Drug Safety approved Tabrecta and Tepmetko together on the 23rd. Both are targeted therapies that target MET mutations and have the same indications. Tabrecta and Tepmetko may both be used to treat locally advanced or metastatic NSCLC harboring MET exon 14 skipping mutations.

Various mutations that induce cancer cell growth occur in NSCLC. Dysregulation in the proto-oncogene MET that is located in the long arm of chromosome 7 is also one of such many mutations. MET dysregulation
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