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  • NSCLC standard treatment options undergo major change
  • by Son, Hyung Min | translator Hong, Ji Yeon | Nov 11, 2025 06:07am
Leclaza + Rybrevant combination listed as a NCCN Preferred therapy for first-line treatment
Tagrisso + chemotherapy combination is also Category 1¡¦studies on combination therapies are actively pursued
 ¡ã Yuhan
The Leclaza + Rybrevant combination therapy has been recommended as the first-line treatment option by the National Comprehensive Cancer Network (NCCN) guidelines, based on its clinical utility. With Tagrisso also listed as a preferred therapy in combination with platinum-based chemotherapy, combination therapy is expected to become the major strategy in first-line treatment for EGFR-positive non-small cell lung cancer (NSCLC).

According to industry sources on November 8, the NCCN recently revised its NSCLC treatment guidelines, including the combination of Yuhan's 'Leclaza (lazertinib)' and Janssen's 'Rybrevant (amivantamab)' as a Category 1 Preferred, first-line recommendation for EGFR-positive NSCLC.

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