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  • Adding amiloride effective in resistant hypertension
  • by Son, Hyung Min | translator Alice Kang | Jul 9, 2025 06:08am
with fewer side effects
Sungha Park, Professor of Cardiology, Severance Hospital
Possibility rises for its use as an alternative to spironolactone...non-inferiority proven through a randomized controlled trial
¡°Has sufficient clinical value when considering side effects and compliance¡±...expectations rise on its inclusion in practice guidelines
 ¡ã Sungha Park, Professor of Cardiology, Severance Hospital
A new treatment option has been proposed for patients with resistant hypertension that cannot be controlled even with the existing triple combination therapy for hypertension. A regimen combining an olmesartan-based triple combination therapy with the potassium-sparing diuretic ¡®amiloride¡¯ demonstrated similar blood pressure-lowering effects to spironolactone, which was previously recommended as a fourth-line treatment, with fewer side effects.

The SPARE study, led by Professor Sungha Park of the Department of Cardiology at Severance Hospital, was published in the international medical journal JAMA, attracting significant attention.

During an interview with Dailypharm, Professor Park emphasized that the amilo
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